Estrogen therapy increased risk of developing kidney stones

A new report has suggested that the use of estrogen therapy is associated with an increased risk of developing kidney stones in postmenopausal women. Using data from the national Women's Health Initiative study, Naim M. Maalouf, of the University of Texas Southwestern Medical Center, Dallas, examined data from two trials.

10,739 postmenopausal women with hysterectomy who received either an estrogen-only treatment or matching placebo and 16,608 postmenopausal women without hysterectomy who received either an estrogen plus progesterone treatment or matching placebo. Data were collected for an average of 7.1 years in the estrogen-only trial and 5.6 years for the estrogen plus progestin trial.


A total of 335 cases of kidney stones were reported in the active treatment groups, while 284 cases occurred in the placebo groups. The beginning demographic characteristics and risk factors for kidney stones were similar in the two groups.

Estrogen therapy was associated with a significant increase in risk of kidney stones. The corresponding annualized incidence rate per 10,000 women per year was 39 in the treatment group and 34 in the placebo group.

Source: http://www.aboutthehealth.com/2010/10/estrogen-therapy-increased-risk-of.html

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